Everyone’s depression is different, but Ted, a 40-year-old resident of Portland, Oregon, describes his as a “continuous dark veil — a foul, dark, awful perspective that informs every moment of […]
A hallucinogenic drug known on the street as “Special K” offers new hope to those suffering from severe, treatment-resistant depression. Ketamine, which was originally developed in the 1960s as a […]
Abstract BACKGROUND: Antidepressant response to a single sub-anesthetic dose infusion of the glutamatergic modulator ketamine is transient in most depressed patients; however, a minority continue to experience an extended response. […]
Abstract Ketamine was introduced into clinical practice in the 1960s and continues to be both clinically useful and scientifically fascinating. With considerably diverse molecular targets and neurophysiological properties, ketamine’s effects […]
INTRODUCTION: Ketamine’s efficacy in depressive disorders has been established in several controlled trials. The aim of the present study was to determine whether or not ketamine administration significantly improves depressive […]
Excerpts of PBS SoCal show on the drug ketamine for the treatment of depression.
Ronald S. Duman, PhD, Elizabeth Mears, Ph.D., and House Jameson, Ph.D., Professor of Psychiatry and Professor of Neurobiology and of Pharmacology at Yale School of Medicine, discuss advances in the […]
Date: January 7, 2014 Source: RIKEN Summary: PET molecular imaging of the brain reveals that ketamine may act as an antidepressant by boosting serotonin activity in brain areas involved in […]
Date: May 18, 2016 Source: Penn State Summary: New research demonstrates the effectiveness of ketamine to treat depression in a mouse model of the disease. The brings together two hypotheses: […]
Date: May 10, 2016 Source: Massachusetts General Hospital Summary: Repeat ketamine infusions decreased — and for some, eliminated — suicidal thoughts in outpatients with treatment-resistant depression, report investigators.